Olefin metathesis for chemical biology

Wezenbergand Ben L. Boekema, Depeng ZhaoMarc C. Stuart, and Ben L.

Olefin metathesis for chemical biology

Click Chemistry Publications Zhang, Y. Tetrahedron63, Combining Proline and 'Click Chemistry': Asymmetry17, Acta40, A Click Chemistry Approach to Glycomimetics: Design, Synthesis, and Antibody Binding Study.

Nature London, Biomacromolecules8, Macromolecules40, Grafting of Poly[2- tert-butylamino ethyl methacrylate] onto Polypropylene by Reactive Blending and Antibacterial Activity of the Copolymer. Toxicology, Biochemistry46, Ultrathin, Responsive Polymer Click Capsules.

Biomaterials28, Synthesis and Application of Glycopeptide and Glycoprotein Mimetics. Development of O-Acyl Isopeptide Method. Peptide Science88, Synthesis of Functionalized Bisphosphonates via Click Chemistry.

Azide End-Capped Hyperbranched Polyglycerol: Complex Polymer Structures via Click Chemistry. Rapid Synthesis of 5-Butynyl-1,2,3-Triazoles.

Olefin metathesis for chemical biology

Rod-Coil Copolymers from Oligo p-benzamide Foldamers. Nucleosides and Oligonucleotides with Diynyl Side Chains: Acta90, Oligonucleotides Forming an i-motif: Macromolecular Chemistry Nachrichten aus der Chemie55, Protein Immobilization Strategies for Protein Biochips.

Synthesis of a Benzolactone Collection using Click Chemistry. Discovery4, Multi-Site Modification of Neomycin B: Combined Mitsunobu and Click Chemistry Approach. American Biotechnology Laboratory25, Acta52, ChemMedChem2, In Methods and Reagents for Green Chemistryp Estrogenic Analogues Synthesized by Click Chemistry.

Organometallics26, Applications of Polymer Bioconjugates. Aziridines in Parallel- and Solid-Phase Synthesis.Phillip Taylor is continuing work in the Kennepohl Group to investigate the electronic structure of ruthenium-based olefin metathesis catalysts.

Using a combination of computational and spectroscopic methods, Phillip is developing an experimentally-verified description of the catalytic species and defining its relationship to the observed chemical reactivity of these.

In particular, Grubbs has worked on olefin metathesis.

Richard R. Schrock - Wikipedia

Prior to Grubbs's work, metathesis was poorly understood and of limited value to scientists. Grubbs developed powerful new catalysts for metathesis that enabled custom synthesis of valuable molecules, such as pharmaceuticals and new polymers with novel materials properties.

PdSeO 3 Monolayer: Promising Inorganic 2D Photocatalyst for Direct Overall Water Splitting Without Using Sacrificial Reagents and Cocatalysts. Zhang, Y.-H.; Gao, Z.-X.; Zhong, C.-L.; Zhou, H.-B.; Chen, L.; Wu, W.-M.; Peng, X.-J.; Yao, Z.-J. An Inexpensive Fluorescent Labeling Protocol for Bioactive.

Site-selective protein modification has become an important tool to study protein functions in chemical biology. The bio-orthogonal chemical reaction of choice was olefin metathesis.

In organic chemistry, an alkene is an unsaturated hydrocarbon that contains at least one carbon–carbon double bond. The words alkene and olefin are often used interchangeably (see nomenclature section below).


Acyclic alkenes, with only one double bond and no other functional groups, known as mono-enes, form a homologous series of .

The allylic chalcogen effect in olefin metathesis - CORE